Research Program

Clinical Pharmacokinetics and Pharmacogenomics Research Unit

The research theme of the Clinical Pharmacokinetics and Pharmacogenomics Research Unit (CPPRU) includes, but is not limited, to the study of clinical pharmacokinetics of various kinds of drugs looking at the dosage regimen and therapeutic drug monitoring in patients and also the studies of the relationships between pharmacokinetics, pharmacodynamics, and pharmacogenomics. All the research arises from real clinical problems in patients’ treatment. Thus, the results are implemented into clinical practice and are developed further as a point of care services, for example, the measurements of drug and biomarker levels in biological fluids and the pharmacogenetic/ pharmacogenomics testing.

Focus Areas

  • CYP3A and drug transporters activity changes in Thai elderly with or without chronic kidney disease using a microdose cocktail
  • The correlation of area under the curve with single time point concentration of mycophenolic acid and its metabolite in Thai kidney transplant recipients receiving enteric-coated mycophenolate sodium
  • Greater optimisation of pharmacokinetic/pharmacodynamic parameters through a loading dose of intravenous colistin in paediatric patients
  • Clinical Pharmacokinetics of piperacillin in pediatric patients
  • Clinical efficacy of HydroZitLa in reducing risk factors of urinary stone disease: Clinical trial phase 1 safety in healthy volunteers
  • Clinical Pharmacokinetics of piperacillin in pediatric patients
  • Pharmacokinetics and pharmacodynamics of meropenem in pediatric patients
  • Evaluation of the Stability, Efficacy, and Sterility of Repackaged Ziv-aflibercept for Intravitreal Administration
  • Pharmacokinetic study of intravenous colistin in pediatric population
  • Pharmacokinetics of Rifapentine in Thai pediatrics patients with latent TB infection
  • Pharmacokinetic study and safety of levofloxacin in pediatric TB patients
  • CYP2D6 predicts plasma donepezil concentrations in a cohort of Thai patients with mild to moderate dementia
  • Effect of NUDT15 variants to levels of Thiopurine metabolite
  • Dementia patients CYP2D6 long read sequencing
  • Correlation of CYP2D6 polymorphism to pharmacokinetic and pharmacodynamics of primaquine in Thai soldier population
  • CYP3A5 polymorphism and the effects on plasma tacrolimus dose requirement in Thai liver transplantation: donor and recipients

Partnerships

Faculty of Medicine
Chula Clinical Research Center
Center for Medical Diagnostic
Laboratories (CMDL)

Thailand Center of Excellence
for Life Sciences

Faculty of Allied
Health Sciences

Faculty of Pharmaceutical
Sciences

Publications National & International

  • Phaisal W, Chariyavilaskul P, Avihingsanon Y, Wittayalertpanya S. High Performance Liquid Chromatography Assay for a Determination of Inosine Monophosphate Dehydrogenase Activity in Human Peripheral Blood Mononuclear Cells. Proceedings of 35th Pharmacological and Therapeutic Society of Thailand Meeting. 2013:81-85.
  • Kittanamongkolchai W, Rukrung C, Supasiri T, Lertjirachai I, Somparn P, Chariyavilaskul P, Avihingsanon Y. Therapeutic drug monitoring of mycophenolate mofetil for the treatment of severely active lupus nephritis. Lupus. 2013 Jun;22(7):727-32.
  • Thongliamnak N, Chariyavilaskul P, Indrampanya T, Wittayalertpanya S. Effect of low body temperature on pharmacokinetics of propofol. Proceedings of 36th Pharmacological and Therapeutic Society of Thailand Meeting. 2014:71-75.
  • Wittayalertpanya S, Chariyavilaskul P, Prompila N, Sayankuldilok N, Eiamart W. Pharmacokinetics and bioequivalence study of irbesartan tablets after a single oral dose of 300 mg in healthy Thai volunteers. Int J Clin Pharmacol Ther. 2014 May;52(5):431-6.
  • Reis A, Rudnitskaya A, Chariyavilaskul P, Dhaun N, Melville V, Goddard J, Webb DJ, Pitt AR, Spickett CM. Top-down lipidomics of low-density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease. J Lipid Res. 2015 Feb;56(2):413-22.
  • Chariyavilaskul P, Poungpairoj P, Chaisawadi S, Boonla C, Dissayabutra T, Prapunwattana P, Tosukhowong P. In vitro anti-lithogenic activity of lime powder regimen (LPR) and the effect of LPR on urinary risk factors for kidney stone formation in healthy volunteers. Urolithiasis. 2015 Apr;43(2):125-34.
  • Namjud N, Chariyavilaskul P, Townamchai N, Wittayalertpanya S. A reduction of asymmetric dimethylarginine in renal transplant recipients receiving sirolimus-based regimen. J Med Assoc Thai. 2015 Jan;98 Suppl 1:S9-13.
  • Sukkummee V, Wittayalertpanya S, Wonganan P, Chariyavilaskul P, Leelahavanichkul A. Effects of chronic kidney disease on intestinal drug transporters in a mouse model. Proceedings of 13th Asia Pacific Federation of Pharmacologist (APFP) Meeting. 2015:84.
  • Dhaun N, Yuzugulen J, Kimmitt RA, Wood EG, Chariyavilaskul P, MacIntyre IM, Goddard J, Webb DJ, Corder R. Plasma pro-endothelin-1 peptide concentrations rise in chronic kidney disease and following selective endothelin A receptor antagonism. J Am Heart Assoc. 2015 Mar 23;4(3):e001624
  • Townamchai N, Chancharoenthana W, Vadcharavivad S, Chariyavilaskul P, Pongpirul K, Leelahavanichkul A, Watanatorn S, Avihingsanon Y, Praditpornsilpa K, Srisawat N. A Simple Novel Technique to Estimate Tacrolimus Dosages During the Early Post Kidney Transplantation Period. Transplant Proc. 2015 Oct;47(8):2433-8.
  • Buathong N, Kalayasiri K, Chariyavilaskul P, Phetnoi K,  Ratananupong T. Association of cytochrome P450 2A6 polymorphism, anxiety and environmental factors with cigarette smoking by Thai adults. Asian Biomedicine. 2016 April;10(2):147-154.
  • Veerakikosol K, Chariyavilaskul P, Townamchai N, Wittayalertpanya S. Association of CYP3A5 and POR polymorphisms with the maintenance tacrolimus dosage requirement in Thai recipients of kidney transplants. Asian Biomedicine. 2016 Oct;10(5):483-490.
  • Peerapornratana S, Chariyavilaskul P, Kanjanabuch T, Praditpornsilpa K, Eiam-Ong S, Katavetin P. Short-Dwell Cycling Intraperitoneal Cefazolin Plus Ceftazidime in Peritoneal Dialysis Patients. Perit Dial Int. 2017 Mar-Apr;37(2):218-224
  • Prompila N, Eiamart W, Jumroen Y, Sayankuldilok N, Chariyavilaskul P, Ketchat W, Wittayalertpanya S. Pharmacokinetics and bioequivalence of a pregabalin 150-mg capsule in healthy Thai subjects. Int J Clin Pharmacol Ther. 2017 May 17.
  • Chunsangchan M, Chariyavilaskul P, Ketchart W, Prompila N, Wittayalertpanya S. Bioequivalence and pharmacokinetic/pharmacodynamic correlation of clopidogrel in healthy Thai subjects. Int J Clin Pharmacol Ther. 2017 Dec;55(12):915-922.
  • Udomkarnjananun S, Townamchai N, Chariyavilaskul P, Iampenkhae K, Pongpirul K, Sirichindakul B, Panumatrassamee K, Vanichanan J, Avihingsanon Y, Eiam-Ong S, Praditpornsilpa K. The Cytochrome P450 3A5 Non-Expressor Kidney Allograft as a Risk Factor for Calcineurin Inhibitor Nephrotoxicity. Am J Nephrol. 2018;47(3):182-190.
  • Songvut P, Chariyavilaskul P, Tantisira MH, Khemawoot P. Safety and Pharmacokinetics of Standardized Extract of Centella asiatica (ECa 233) Capsules in Healthy Thai Volunteers: A Phase 1 Clinical Study. Planta Med. 2019 Apr;85(6):483-490.
  • Sukkummee W, Jittisak P, Wonganan P, Wittayalertpanya S, Chariyavilaskul P, Leelahavanichkul A. The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison. Ren Fail. 2019 Nov;41(1):314-325.
  • Chamnanphon M, Gaedigk A, Puangpetch A, Pasomsub E, Chantratita W, Longley RJ, Sattabongkot J, Chariyavilaskul P, Sukasem C. Pharmacogene Variation in Thai Plasmodium vivax Relapse Patients Treated with a Combination of Primaquine and Chloroquine. Pharmgenomics Pers Med. 2020 Jan 10; 13:1-12.
  • Triyawatanyu P, Chariyavilaskul P, Phaisal W, Peerapornratana S, Kanjanabuch T, Praditpornsilpa K, Katavetin P. Intraperitoneal cefazolin and ceftazidime during short-dwell exchange in peritoneal dialysis patients with peritonitis. Perit Dial Int. 2020 Mar;40(2):179-184.
  • Wacharachaisurapol N, Phasomsap C, Sukkummee W, Phaisal W, Chanakul A, Wittayalertpanya S, Chariyavilaskul P, Puthanakit T. Greater optimisation of pharmacokinetic/pharmacodynamic parameters through a loading dose of intravenous colistin in paediatric patients. Int J Antimicrob Agents. 2020 Mar 13:105940. doi: 10.1016/j.ijantimicag.2020.105940. [Epub ahead of print].
  • Thammathiwat T, Tiranathanagul K, Limjariyakul M, Chariyavilaskul P, Takkavatakarn K, Susantitaphong P, Meesangnin S, Wittayalertpanya S, Praditpornsilpa K, Eiam-Ong S.Super High-Flux Hemodialysis Provides Comparable Effectiveness With High-Volume Post-dilution Online Hemodiafiltration in Removing Protein-bound and Middle-molecule Uremic Toxins: A Prospective Cross-over Randomized Controlled Trial. Ther Apher Dial. 2020 May 1. doi: 10.1111/1744-9987.13508. Online ahead of print.
  • Ratprasatporn N, Wittayalertpanya S, Khemsri W, Chatsuwan T, Chongpison Y, Chamsai T, Wattanakijkarn M, Chansangpetch S. Stability and Sterility of Extemporaneously Prepared Nonpreserved Cefazolin, Ceftazidime, Vancomycin, Amphotericin B, and Methylprednisolone Eye Drops. Cornea. 2019 Aug;38(8):1017-1022.
  • Singhan W, Vadcharavivad S, Areepium N, Wittayalertpanya S, Chaijamorn W, Srisawat N. The effect of direct hemoperfusion with polymyxin B immobilized cartridge on meropenem in critically ill patients requiring renal support. J Crit Care. 2019 Jun;51:71-76.
  • Janewongwirot P, Jantarabenjakul W, Anugulruengkitt S, Anunsittichai O, Saengseesom W, Buranapraditkun S, Sophonphan J, Wacharachaisurapol N, Jitrungruengnij N, Pancharoen C, Puthanakit T. A randomized open-label trial of 2-dose or 3-dose pre-exposure rabies prophylaxis among Thai children. Vaccine. 2019 Aug 23;37(36):5307-5313.
  • Wacharachaisurapol N, Bender JM, Wang L, Bliss D, Ponrartana S, Pannaraj PS. Abdominal Actinomycosis in Children: A Case Report and Literature Review. Pediatr Infect Dis J. 2017 Mar;36(3):e76-e79.
  • Jitrungruengnij N, Anugulruengkitt S, Rattananupong T, Prinyawat M, Jantarabenjakul W, Wacharachaisurapol N, Chatsuwan T, Janewongwirot P, Suchartlikitwong P, Tawan M, Kanchanabutr P, Pancharoen C, Puthanakit T; D-CLaB study team. Efficacy of chlorhexidine patch on central line-associated bloodstream infections in children. Pediatr Int. 2020 Feb 17. doi: 10.1111/ped.14200. Online ahead of print.

Contact

Assistant Professor Pajaree Chariyavilaskul

Chulalongkorn University, Payathai road, Payathai District, Pathumwan, Bangkok, 10330.
Tel.: (081) 613-4664
E-mail: pajaree.l@chula.ac.th