Research Program

Critical Care Nephrology Research Unit

Critical care nephrology is an emerging field in medicine combining intensive care medicine and nephrology in order to provide the optimum care for critically ill patients with acute kidney injury (AKI) and multiorgan dysfunction. Established in 2019 by Associated Professor Dr. Nattachai Srisawat and team, the Critical Care Nephrology Research Unit (CCNRU) of Chulalongkorn University is a multidisciplinary group with the goal of developing study and innovation that provides novel insights in basic knowledge, translational, and clinical sciences of AKI to improve the outcome of AKI in Thailand and South East Asia. We are a pioneer of AKI research in this region and have a strong collaboration with other world-wide centers.

Focus Areas

Acute Kidney Injury

  • Epidemiology and Long term Outcome of Critically Ill Patients Requiring Renal Replacement Therapy in Southeast Asia and India (InSEA-RRT Registry)
  • The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
  • Peritoneal dialysis versus hemodialysis in acute kidney injury
  • Assessment of renal function with serum cystatin c in critically ill survivors from intensive care units
  • Standard versus Comprehensive Care for Post-Acute Kidney Injury: A Randomized Controlled Trial
  • Revalence of and Factors Associated with Physician-Surrogate Decision Makers DISCordance about RRT Prognostication in Critically Ill Patients (DISC-RRT)
  • Citrate Pharmacokinetic Study in Decompensated Liver Disease Patients Receiving Continuous Renal Replacement Therapy
  • Citrate versus Heparin in Continuous Renal Replacement Therapy: Effect on Cardiovascular System and Clot Circuit in Critically Ill Patients
  • STOP-AKI
  • TIME-RRT
  • ASSIST-RRT
  • AI-RRT
  • PREDICT-CKD
  • INSPIRE-AI

Tropical Medicine

  • Study of Prediction Severe Dengue Disease by Using Novel Biomarkers
  • The correlation between Leptospiral load, Leptospires species and disease severity of leptospirosis
  • Comprehensive Care of Leptospirosis in Thailand (Care-LEPTO Project)
  • Follow-up post leptospirosis
  • Characterizing Disease in Non-leptospirosis group
  • Nanostring in Leptospirosis
  • Hemoperfusion in severe COVID-19 patients
  • Endotoxemia and circulating bacteriome in severe COVID-19 patients
  • Prevalence of acute kidney injury in COVID-19 patients
  • Seroprevalence of COVID-19
  • Specific monoclonal antibody of COVID-19

Innovation

  • Development Point of Care Testing of Albuminuria for Early Screening Chronic Kidney Disease
  • Urine Output Measurement Device (UROM)
  • Integration of Electrochemical Biosensor and Reader for Blood Lactate Detection
  • ASSIST-RRT

Partnerships

King Chulalongkorn
Memorial Hospital.
Universiti Sains Malaysia
Siam Cement Group

University of Kebangsaan

Health Systems Research
Institute (HSRI)


Institute of Biotechnology
and Genetic Engineering,
Chulanlongkorn Usiversity. (IBGE-CU)

Luangprabang
Provincial Hospital, Laos.

Maharaj Nakhon Si Thammarat
Hospital

Maharat Nakhon
Ratchasima Hospital

Mahasarakham
Hospital
Metallurgy and Materials
Science Research Institute (MMRI)

Mittaphab Hospital, Laos.

Nakornping Hospital
Nan Hospital

National Innovation Agency (NIA)


Serve Science Co., Ltd.


Sichon Hospital

Suthavaj Hospital
(Faculty of Medicine
Mahasarakham University)

Thabo Crown Prince
Hospital

Thammasat Universiry
Hospital

The Kidney Foundation
of Thailand


The Medical Council
of Thailand

Thungsong Hospital

Vajira Hospital


Vidyasirimedhi institute
of science and Technology (VISTEC)


Sirivadhanabhakdi
Foundation


The Royal College
of Physicians of Thailand


Siam University


Banpong Hospital


Photharam Hospital


National Blood Centre
The Thai Red Cross Society.


Nakhon Si Thammarat
Provincial Public Health OfficePhotharam Hospital


Sisaket Provincial
Public Health Office


Baxter Healthcare
Corporation


Bhumibol Adulyadej
Hospital



Buddhachinaraj Phitsanulok Hospital


Center of Excellence for Biomedical
and Public Health Informatics (BIOPHICS)


Chula Excellence Center of Systems Biology,
Chulalongkorn University


Excellence Center for Critical Care Nephrology



National Electronics and Computer Technology Center (NECTEC)



Cho Ray hospital, Vietnam



Chiang Mai University



University of Malaya



  • Savannakhet Provincial Hospital, Laos.
  • Champasak Hospital, Laos.
  • Gatot Soebroto Indonesia Army Central Hospital, Indonesia.

Research Highlights

Publications National & International

  • Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta analysis of randomised clinical trials. 2020. Lancet.
  • Development and Validation of a simple score for diagnosis of Leptospirosis at outpatient departments. 2020. PLoS Negl Trop Dis.
  • Epidemiology and outcomes of acute kidney injury among patients in the Intensive Cre Unit in Laos: a nationwide multicenter, prospective, and observational study. 2020. BMC Medicine.
  • Urine neutrophil Gelatinaseassociated Lipocalin (nGAL) for prediction of persistent AKi and Major Adverse Kidney events. 2020. Scientific Report.
  • The Role of Biomarkers in Acute Kidney Injury. 2020. Crit Care Clin.
  • THAI-ICU score as a simplified severity score for critically ill patients in a resource limited setting: Result from SEA-AKI study group. 2020. J Crit Care.
  • SEA-MAKE score as a tool for predicting major adverse kidney events in critically ill patients with acute kidney injury: results from the SEA-AKI study. 2020. Ann Intensive Care.
  • The role of neutrophil chemotaxis activity as an immunologic biomarker to predict mortality in critically-ill patients with severe sepsis. 2020. J Crit Care.
  • Incidence of acute kidney injury and use of renal replacement therapy in intensive care unit patients in Indonesia. 2020. BMC Nephrology.
  • The haemodynamic effects of oXiris haemofilter in septic shock patients requiring renal support: A single-centre experience. 2020. Int J Artif Organs.

Contact

Faculty of Medicine

Critical Care Nephrology Research Unit King Chulalongkorn Memorial Hospital   1873 Rama IV. Pathumwan, Bangkok 10330
Tel.: (+66) 22564000 (3597, 3679)
E-mail: ec-ccn_chulahos@hotmail.com
  • Face book: Excellence Center for Critical Care Nephrology